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| Product Name |
Heptafluorobutyric acid |
| Model No |
SIL136F |
| Cas No. |
375-22-4 |
| Assay |
95% ,98% |
| Molecular Structural |
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| Details: |
Product Name:Heptafluorobutyric acid
Chemical Properties:Clear colorless to faintly yellow liquid
CAS:375-22-4
MF:C4HF7O2
MW:214.04
Melting point -17.5 °C
Boiling point 锛120 °C755 mm Hg(lit.)
Density锛1.645 g/mL at 25 °C(lit.)
Vapor density 锛7 (vs air)
Vapor pressure:~10 mm Hg ( 25 °C)
Refractive index :n20/D 1.3(lit.)
Fp :120-121°C
Storage temp. :Store below +30°C.
Pka:pK1:0.17 (25°C)
Specific Gravity:approximate 1.6
PH:1 (H2O, 20鈩)
Water Solubility:miscible
Uses:Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.
Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.
Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.
Perfluorobutyric acid is an effective additive for zinc electrodeposition. |
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